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Present day protagonist Desmond Miles' mind has suffered a breakdown from the events of the previous games, and to save Desmond's mind, the Assassins put him into a specialized safe area of the Animus. Upon awakening inside the Animus, Desmond meets Subject 16, who occupied the Animus before him. 16 explains that Desmond's mind is fragmented, and that the only way for him to separate the pieces of his true self from those of his ancestors is to continue to play out their stories until there is nothing left for them to show Desmond. Once he reaches that point, the Animus will be able to separate the three individual's memories.